Obesity and type 2 diabetes harm bone health

Obesity and Type 2 diabetes have been linked to several health issues, including an increased risk of bone fractures, says a study.


University of Missouri researchers examined the development of obesity and insulin resistance contribute to bone-fracture risk and exercise prevents weight gain, diabetes and protects bone health, British channel reported.

They found obesity and Type 2 diabetes negatively affected bone, but exercise prevented weight gain and diabetes and increased bone strength.

Researchers once thought obesity was protective of bone because with more body mass, individuals have more bone mass; more bone mass typically decreases risk of osteoporosis and associated fractures.

Researchers examined how the development of obesity and Type 2 diabetes affect bone structure, formation and strength over time. Specifically, the researchers studied the bones of rats that had a predisposition to overeat, which caused the rats to gain weight and become insulin resistant.

This pattern of weight gain and insulin resistance parallels the development of obesity and Type 2 diabetes in humans.

The researchers allowed half of the rats to overeat and voluntarily exercise on running wheels; the other rats programmed to overeat remained sedentary. The researchers also had a control group of non-overeating rats that remained sedentary.

The researchers studied bones from rats in the three groups at different ages to determine how early in the development of obesity and diabetes the bone was affected negatively.

These findings could inform interventions to improve bone health among individuals with obesity and Type 2 diabetes.