An explosion inside Cairo’s Coptic cathedral killed at least 25 people, most of them women, and injured 49, Egypt’s state television said.
Security sources told Reuters that at least six children were among the dead.
There was no immediate claim of responsibility.
A device containing about 12 kg of the explosive TNT had denoted on the women’s side of the cathedral, the security sources said.
“As soon as the priest called us to prepare for prayer, the explosion happened,” Emad Shoukry, who was inside the cathedral when the blast took place, told Reuters.
“The explosion shook the place… The dust covered the hall and I was looking for the door, although I couldn’t see anything… I managed to leave in the middle of screams and there were a lot of people thrown on the ground,” he said.
Orthodox Copts, who make up about 10 percent of Egypt’s 90 million people, are the Middle East’s biggest Christian community. They have long complained of discrimination under successive Egyptian leaders.
Militants are waging an insurgency led by Islamic State’s branch in North Sinai, where hundreds of soldiers and police have been killed.
The insurgents have also launched deadly attacks Cairo and other cities.
On Friday, two roadside bombs — one in Cairo and one north of the capital — killed six policemen and wounded six others.